Holders Wigan Warriors will continue their defence of the Tetley's Challenge Cup trophy with a compelling home quarter-final against Castleford Tigers.
The Super League rivals were paired together in a tie which provides the highlight of a round which features some intriguing fixtures.
Castleford have been one of the form teams of Super League in 2014 and have already beaten Wigan this season, although with home advantage the Warriors will be strongly fancied to take another step nearer the final at Wembley Stadium on Saturday August 23.
Super League leaders Leeds Rhinos, who are the bookmakers' favourites to win at Wembley, have a home tie against Championship leaders Leigh Centurions, the only professional club with a 100 per cent record in 2014,
Bradford Bulls will host Warrington Wolves in the last eight whilst Keighley Cougars, the second Championship club in the quarter-finals, will travel to Widnes Vikings in a repeat of the 1937 Wembley final.
The draw was conducted by Rugby League legends Paul Sculthorpe MBE and Jason Robinson OBE and was broadcast live on the BBC News channel.
The draw in full is as follows:
Wigan Warriors v Castleford Tigers
Leeds Rhinos v Leigh Centurions
Bradford Bulls v Warrington Wolves
Widnes Vikings v Keighley Cougars.
Tickets for the 2014 Tetley’s Challenge Cup final at Wembley Stadium on Saturday August 23 cost from as little as £22 and can be purchased by calling the 24-hour Ticket Hotline on 0844 856 113 or by visiting www.rugbyleaguetickets.co.uk.